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There is no doubt that vaccines play an important role in combating infectious disease saving 2-3 million lives around the world. Vaccines eradicated smallpox that killed hundreds of millions of people around the world. Vaccines decrease childhood mortality and prevent life-long disability like polio that can cause paralysis and major disability. However, while there are clear examples of success stories for vaccines; we should be cautiously optimistic about the true benefit of vaccines. Vaccines prevent disease, but do not treat disease. In healthy immune systems (immunocompetent), vaccines prime the body to make antibodies to prevent the attachment of virus (Coronavirus) and block the binding to host cells and can eliminate extracellular virus. However, intracellular pathogens like viruses require cellular immunity to deal with infection or disease. (Vaccines do not treat disease or infection once it occurs).

Healthy children and adults likely will develop antibodies without experiencing any symptoms or just experience mild symptoms, which is the rule rather than the exception with Coronavirus; making spread of the disease less important as long of the severity of the disease remains limited. Older patients with multiple medical problems and frail are would ordinarily benefit from a vaccine if they are can mount an immune response. In effect, those patients at highest risk for infection do not respond as well as compared to younger people who are immunocompetent.

There are 35 vaccines around the world being developed as a global health network in a few major cities in the United States, Europe, and South East Asia (China, Singapore, Hong Kong and Japan) and India collectively can now develop mRNA Vaccines and shorten a 10-year process to less than 2 years providing disease enhancement is kept low. Normally, vaccines undergo phases from animal research to phase 1 trials (20-80 human participants), then to phase 2 trials (100-300 participants) where there is an outbreak or endemic area and then to phase 3 trials (1000 or more participants in endemic areas). Coronavirus is a positive-sense RNA virus (Just like the MRNA viruses being developed that change the landscape for vaccination development and timeframe for development) that is a technology to prevent disease. Remember preventing disease is not the same as creating health. Moreover, follow the money; who is getting it, and who is losing it. The Coronavirus spreads across populations and for the most part mostly causes mild disease, which is not to say it cannot be deadly to high-risk people who absolutely deserve all of the best efforts to mitigate. Throughout nature, infection without disease is the rule rather than the exception. I will finish as I have started, "Not everything that counts can be counted; And not everything that can be counted counts." With new vaccines on the horizon, mRNA vaccines the epidemiologists have a hammer to prevent disease (not treat disease); lets hope that everything does not look like a nail.

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